INDICATED FOR THE TERATMENT OF INDIVIDUALS SUSPECTED OF CONTAMINATION WITH PLUTONIUM, AMERICIUM OR CURIUM TO INCREASE THE RATE OF ELIMINATION.
CHELATION TREATMENT IS MOST EFFECTIVE IF ADMINISTERED WITHIN THE FRST 24 HOURS AFTER INTERNAL CONTAMINATION WHEN THE RADIOCONTAMINANTS ARE STILL CIRCULATING OR ARE IN INTERSTITIAL FUIDS AND SHOULD BE STARTED AS SOON AS POSSIBLE.
INDIVIDUALS SHOULD DRINK PLENTY OF FLUIDS AND VOID FREQUENTLY TO PROMOTE DILUTION OF THE RADIOACTIVE CHELATE IN THE URINE AND MINIMIZE RADIATION EXPOSURE DIRECTLY TO THE BLADDER.
IT IS PREFERABLE TO ADMINISTER CA-DTPA, IF AVAILABLE, AS THE INITIAL DOSE DURING THE FIRST 24 HOURS AFTER INTERNAL CONTAMINATION BECAUSE CA-DTPA IS MORE EFFECTIVE THAN ZN-DTPA DURING THIS TIME PERIOD. AFTER 24 HOURS, ZN-DTPA AND CA-DTPA ARE EQUALLY EFFECTIVE. IT IS ADMINISTERED EITHER WITH A SLOW INTRAVENOUS PUSH OVER A PERIOD OF 3-4 MINUTES OR BY INTRAVENOUS INFUSION OVER 30 MINUTES DILUTED IN 100-250 ML OF 5% DEXTROSE IN WATER (D5W), RINGERS LACTATE, OR NORMAL SALINE.
ADULTS AND ADOLESCENTS :
A SINGLE 1.0 GRAM INITIAL DOSE OF ZN-DTPA ADMINISTERED INTRAVENOUSLY.
PEDIATRICS (LESS THAN 12 YEARS OF AGE):
A SINGLE INITIAL DOSE OF 14 MG/KG ADMINISTERED INTRAVENOUSLY NOT TO EXCEED 1.0 GRAM.
MAINTENANCE TREATMENT ADULTS AND ADOLESCENTS
THE RECOMMENDED MAINTENANCE DOSE OF ZN-DTPA IS 1.0 GRAM ONCE A DAY ADMINISTERED INTRAVENOUSLY.
PEDIATRICS (LESS THAN 12 YEARS OF AGE):
THE RECOMMENDED MAINTENANCE DOSE OF ZN-DTPA IS 14 MG/KG ONCE A DAY ADMINISTERED INTRAVENOUSLY. THE MAXIMUM DAILY DOSE SHOULD NOT EXCEED 1.0 GRAM PER DAY.
THE DURATION OF CHELATION TREATMENT DEPENDS ON THE AMOUNT OF INTERNAL CONTAMINATION AND INDIVIDUAL RESPONSE TO TREATMENT.
ADMINISTRATION BY NEBULIZATION:
IN INDIVIDUALS WHOSE INTERNAL CONTAMINATION IS ONLY BY INHALATION, ZN-DTPA CAN BE ADMINISTERED BY NEBULIZED INHALATION AS AN ALTERNATIVE ROUTE OF ADMINISTRATION. ZN-DTPA SHOULD BE DILUTED FOR NEBULIZATION AT A 1:1 RATIO WITH STERILE WATER OR SALINE. AFTER NEBULIZATION, INDIVIDUALS SHOULD BE ENCOURAGED TO AVOID SWALLOWING ANY EXPECTORANT.