INDICATED FOR USE IN PATIENTS WITH SUBOPTIMAL ECHOCARDIOGRAMS TO OPACIFY THE LEFT VENTRICULAR CHAMBER AND TO IMPROVE THE DELINEATION OF THE LEFT VENTRICULAR ENDOCARDIAL BORDER.
PERFLUTREN LIPID MICROSPHERE MAY BE INJECTED BY EITHER AN INTRAVENOUS (IV) BOLUS OR INFUSION. THE MAXIMUM DOSE IS EITHER TWO BOLUS DOSES OR ONE SINGLE INTRAVENOUS INFUSION.
BOLUS
THE RECOMMENDED BOLUS DOSE FOR ACTIVATED PERFLUTREN LIPID MICROSPHERE IS 10 MICROLITERS (MICROL)/KG OF THE ACTIVATED PRODUCT BY INTRAVENOUS BOLUS INJECTION WITHIN 30-60 SECONDS, FOLLOWED BY A 10 ML SALINE FLUSH. IF NECESSARY, A SECOND 10 MICROLITERS (MICROL)/KG DOSE FOLLOWED BY A SECOND 10 ML SALINE FLUSH MAY BE ADMINISTERED 30 MINUTES AFTER THE FIRST INJECTION TO PROLONG CONTRAST ENHANCEMENT.
INFUSION
THE RECOMMENDED INFUSION DOSE FOR ACTIVATED PERFLUTREN LIPID MICROSPHERE IS VIA AN IV INFUSION OF 1.3 ML ADDED TO 50 ML OF PRESERVATIVE-FREE SALINE. THE RATE OF INFUSION SHOULD BE INITIATED AT 4.0 ML/MINUTE, BUT TITRATED AS NECESSARY TO ACHIEVE OPTIMAL IMAGE ENHANCEMENT, NOT TO EXCEED 10 ML/MINUTE.