INDICATED FOR THE MANAGEMENT OF SEVERE CHRONIC PAIN FOR WHOM INTRATHECAL (IT) THERAPY IS WARRANTED, AND WHO ARE INTOLERANT OF OR REFRACTORY TO OTHER TREATMENT, SUCH AS SYSTEMIC ANALGESICS, ADJUNCTIVE THERAPIES, OR IT MORPHINE.
IT PRIALT SHOULD BE INITIATED AT NO MORE THAN 2.4 MCG/DAY (0.1 MCG/HR) AND TITRATED TO PATIENT RESPONSE. DOSES MAY BE TITRATED UPWARD BY UP TO 2.4 MCG/DAY (0.1 MCG/HR) AT INTERVALS OF NO MORE THAN 2-3 TIMES PER WEEK, UP TO A RECOMMENDED MAXIMUM OF 19.2 MCG/DAY (0.8 MCG/HR) BY DAY 21. DOSE INCREASES IN INCREMENTS OF LESS THAN 2.4 MCG/DAY (0.1 MCG/HR) AND INCREASES IN DOSE LESS FREQUENTLY THAN 2-3 TIMES PER WEEK MAY BE USED.