ALL TYPE-I INTERFERONS SHARE COMMON BIOLOGICAL ACTIVITIES GENERATED BY BINDING OF INTERFERON TO THE CELL-SURFACE RECEPTOR, LEADING TO THE PRODUCTION OF SEVERAL INTERFERON-STIMULATED GENE PRODUCTS. TYPE-I INTERFERONS INDUCE PLEIOTROPIC BIOLOGIC RESPONSES WHICH INCLUDE ANTIVIRAL, ANTIPROLIFERATIVE, AND IMMUNOMODULATORY EFFECTS, REGULATION OF CELL SURFACE MAJOR HISTOCOMPATIBILITY ANTIGEN (HLA CLASS I AND CLASS II) EXPRESSION AND REGULATION OF CYTOKINE EXPRESSION.