ADMINISTRATION MUST BE THROUGH A CENTRAL LINE. MUST BE DILUTED WITH STERILE DEXTROSE INJECTION
ADMINISTRATION THROUGH A PERIPHERAL LINE MAY CAUSE BURNS
IT IS ADMINISTERED INTRAVENOUSLY AS A LOADING DOSE INFUSION ADMINISTERED OVER 90 TO 120 MINUTES, FOLLOWED BY AN EQUIVALENT MAINTENANCE DOSE INFUSION ADMINISTERED OVER 24 HOURS. ADMINISTRATION OF ANALOGOUS ORAL DRUGS, SUCH AS BUPHENYL® (SODIUM PHENYLBUTYRATE), SHOULD BE TERMINATED PRIOR TO AMMONUL® INFUSION.
ONCE ELEVATED AMMONIA LEVELS HAVE BEEN REDUCED TO THE NORMAL RANGE, ORAL THERAPY, SUCH AS SODIUM PHENYLBUTYRATE, DIETARY MANAGEMENT AND PROTEIN RESTRICTIONS SHOULD BE STARTED OR REINITIATED.
AMMONUL® ARGININE HCL
INJECTION, 10% SODIUM PHENYLACETATE, SODIUM BENZOATE, ARGININE HCL
CHILD WT: 0 TO 20 KG:
CPS AND OTC DEFICIENCY
DOSE
LOADING: OVER 90 TO 120 MINUTES
MAINTENANCE: OVER 24 HOURS 2.5 ML/KG 2.0 ML/KG 250 MG/KG 250 MG/KG 200 MG/KG
ASS AND ASL DEFICIENCY
DOSE
LOADING: OVER 90 TO 120 MINUTES
MAINTENANCE: OVER 24 HOURS 2.5 ML/KG 6.0 ML/KG 250 MG/KG 250 MG/KG 600 MG/KG
CPS AND OTC DEFICIENCY
DOSE
LOADING: OVER 90 TO 120 MINUTES
MAINTENANCE: OVER 24 HOURS 55 ML/M² 2.0 ML/KG 5.5 G/M² 5.5 G/M² 200 MG/KG
> 20 KG:
ASS AND ASL DEFICIENCY
DOSE
LOADING: OVER 90 TO 120 MINUTES
MAINTENANCE: OVER 24 HOURS 55 ML/M² 6.0 ML/KG 5.5 G/M² 5.5 G/M² 600 MG/KG