RECOMMENDED DOSE IS 100 MG/M² ADMINISTERED INTRAVENOUSLY OVER 30 MINUTES ON DAYS 1 AND 2 OF A 28-DAY CYCLE, UP TO 6 CYCLES.
TREANDA ADMINISTRATION SHOULD BE DELAYED IN THE EVENT OF GRADE 4 HEMATOLOGIC TOXICITY OR CLINICALLY SIGNIFICANT = GRADE 2 NON-HEMATOLOGIC TOXICITY. ONCE NON-HEMATOLOGIC TOXICITY HAS RECOVERED TO = GRADE 1 AND/OR THE BLOOD COUNTS HAVE IMPROVED [ABSOLUTE NEUTROPHIL COUNT (ANC) = 1 X 109/L, PLATELETS = 75 X 109/L], TREANDA CAN BE REINITIATED AT THE DISCRETION OF THE TREATING PHYSICIAN.
DOSE MODIFICATIONS FOR HEMATOLOGIC TOXICITY: FOR GRADE 3 OR GREATER TOXICITY, REDUCE THE DOSE TO 50 MG/M² ON DAYS 1 AND 2 OF EACH CYCLE; IF GRADE 3 OR GREATER TOXICITY RECURS, REDUCE THE DOSE TO 25 MG/M² ON DAYS 1 AND 2 OF EACH CYCLE.
DOSE MODIFICATIONS FOR NON-HEMATOLOGIC TOXICITY: FOR CLINICALLY SIGNIFICANT GRADE 3 OR GREATER TOXICITY, REDUCE THE DOSE TO 50 MG/M² ON DAYS 1 AND 2 OF EACH CYCLE.
DOSING INSTRUCTIONS FOR NHL :
THE RECOMMENDED DOSE IS 120 MG/M² ADMINISTERED INTRAVENOUSLY OVER 60 MINUTES ON DAYS 1 AND 2 OF A 21-DAY CYCLE, UP TO 8 CYCLES.
TREANDA ADMINISTRATION SHOULD BE DELAYED IN THE EVENT OF A GRADE 4 HEMATOLOGIC TOXICITY OR CLINICALLY SIGNIFICANT = GRADE 2 NON-HEMATOLOGIC TOXICITY. ONCE NON-HEMATOLOGIC TOXICITY HAS RECOVERED TO = GRADE 1 AND/OR THE BLOOD COUNTS HAVE IMPROVED [ABSOLUTE NEUTROPHIL COUNT (ANC) = 1 X 109/L, PLATELETS = 75 X 109/L], TREANDA CAN BE REINITIATED AT THE DISCRETION OF THE TREATING PHYSICIAN.
DOSE MODIFICATIONS FOR HEMATOLOGIC TOXICITY: FOR GRADE 4 TOXICITY, REDUCE THE DOSE TO 90 MG/M² ON DAYS 1 AND 2 OF EACH CYCLE; IF GRADE 4 TOXICITY RECURS, REDUCE THE DOSE TO 60 MG/M² ON DAYS 1 AND 2 OF EACH CYCLE.
DOSE MODIFICATIONS FOR NON-HEMATOLOGIC TOXICITY: FOR GRADE 3 OR GREATER TOXICITY, REDUCE THE DOSE TO 90 MG/M² ON DAYS 1 AND 2 OF EACH CYCLE; IF GRADE 3 OR GREATER TOXICITY RECURS, REDUCE THE DOSE TO 60 MG/M² ON DAYS 1 AND 2 OF EACH CYCLE.