HYDROXYZINE PAMOATE IS UNRELATED CHEMICALLY TO THE PHENOTHIAZINES, RESERPINE, MEPROBAMATE, OR THE BENZODIAZEPINES. HYDROXYZINE PAMOATE IS NOT A CORTICAL DEPRESSANT, BUT ITS ACTION MAY BE DUE TO A SUPPRESSION OF ACTIVITY IN CERTAIN KEY REGIONS OF THE SUBCORTICAL AREA OF THE CENTRAL NERVOUS SYSTEM. PRIMARY SKELETAL MUSCLE RELAXATION HAS BEEN DEMONSTRATED EXPERIMENTALLY. BRONCHODILATOR ACTIVITY, AND ANTIHISTAMINIC AND ANALGESIC EFFECTS HAVE BEEN DEMONSTRATED EXPERIMENTALLY AND CONFIRMED CLINICALLY. AN ANTIEMETIC EFFECT, BOTH BY THE APOMORPHINE TEST AND THE VERILOID TEST, HAS BEEN DEMONSTRATED. CLINICAL EFFECTS ARE USUALLY NOTED WITHIN 15 TO 30 MINUTES AFTER ORAL ADMINISTRATION.