THE CONCOMITANT USE OF OTHER CNS DEPRESSANTS INCLUDING SEDATIVES, HYPNOTICS, TRANQUILIZERS, GENERAL ANESTHETICS, PHENOTHIAZINES, OTHER OPIOIDS, TRICYCLIC ANTIDEPRESSANTS, MONOAMINE OXIDASE (MAO) INHIBITORS, AND ALCOHOL MAY PRODUCE ADDITIVE CNS DEPRESSANT EFFECTS & HYPOTENSION. WHEN SUCH COMBINED THERAPY IS CONTEMPLATED, THE DOSE OF ONE OR BOTH AGENTS SHOULD BE REDUCED.
ANTICHOLINERGICS OR OTHER MEDICATIONS WITH ANTICHOLINERGIC ACTIVITY WHEN USED CONCURRENTLY WITH OPIOID ANALGESICS MAY RESULT IN INCREASED RISK OF URINARY RETENTION AND/OR SEVERE CONSTIPATION, WHICH MAY LEAD TO PARALYTIC ILEUS.
IT HAS BEEN REPORTED THAT THE INCIDENCE OF BRADYCARDIA WAS INCREASED WHEN OXYMORPHONE WAS COMBINED WITH PROPOFOL FOR INDUCTION OF ANESTHESIA.
CNS TOXICITY HAS BEEN REPORTED (CONFUSION, DISORIENTATION, RESPIRATORY DEPRESSION, APNEA, SEIZURES) FOLLOWING COADMINISTRATION OF CIMETIDINE WITH OPIOID ANALGESICS