XIGRIS IS INDICATED FOR THE REDUCTION OF MORTALITY IN ADULT PATIENTS WITH SEVERE SEPSIS (SEPSIS ASSOCIATED WITH ACUTE ORGAN DYSFUNCTION) WHO HAVE A HIGH RISK OF DEATH.
SHOULD BE ADMINISTERED INTRAVENOUSLY AT AN INFUSION RATE OF 24 MCG/KG/HR (BASED ON ACTUAL BODY WEIGHT) FOR A TOTAL DURATION OF INFUSION OF 96 HOURS. DOSE ADJUSTMENT BASED ON CLINICAL OR LABORATORY PARAMETERS IS NOT RECOMMENDED. IF THE INFUSION IS INTERRUPTED, XIGRIS SHOULD BE RESTARTED AT THE 24 MCG/KG/HR INFUSION RATE. DOSE ESCALATION OR BOLUS DOSES OF XIGRIS ARE NOT RECOMMENDED. IN THE EVENT OF CLINICALLY IMPORTANT BLEEDING, IMMEDIATELY STOP THE INFUSION
FOR ADMINISTERING INSTRUCTIONS, SEE DETAILED MONOGRAPH