PAZUFLOXACIN HAS SHOWN MULTIMODAL MECHANISM OF ACTION AND INHIBITS BOTH DNA GYRASE AND TOPOISOMERASE IV ENZYME, LEADING TO INCREASED ANTIBACTERIAL SPECTRUM. MOREOVER, PAZUFLOXACIN HAS BEEN SHOWN TO HAVE DNA ANTAGONISTIC ACTIONS ALSO. THE MULTIMODAL MECHANISM OF ACTION IS LINKED TO THE LOW POTENTIAL FOR THE DEVELOPMENT OF RESISTANCE IN PAZUFLOXACIN. MOREOVER, IT HAS BEEN SHOWN THAT PAZUFLOXACIN IS NOT AFFECTED BY EFFLUX MECHANISM OF RESISTANCE.