CABAZITAXEL IS PRIMARILY METABOLIZED THROUGH CYP3A SO CONCOMITANT ADMINISTRATION OF STRONG CYP3A INHIBITORS E.G., KETOCONAZOLE, ITRACONAZOLE, CLARITHROMYCIN, ATAZANAVIR, INDINAVIR, NEFAZODONE, NELFINAVIR, RITONAVIR, SAQUINAVIR, TELITHROMYCIN, VORICONAZOLE IS EXPECTED TO INCREASE CONCENTRATIONS OF CABAZITAXEL. CYP3A4 INDUCERS E.G. PHENYTOIN, CARBAMAZEPINE, RIFAMPIN, RIFABUTIN, RIFAPENTIN, PHENOBARBITAL, ST. JOHN'S WORT MAY DECREASE CABAZITAXEL PLASMA CONCENTRATIONS.