Name
CEFOTETAN
Mode of Action
THE BACTERICIDAL ACTION OF CEFOTETAN RESULTS FROM INHIBITION OF CELL WALL SYNTHESIS. CEFOTETAN HAS IN VITRO ACTIVITY AGAINST A WIDE RANGE OF AEROBIC AND ANAEROBIC GRAM-POSITIVE AND GRAM-NEGATIVE ORGANISMS. THE METHOXY GROUP IN THE 7-ALPHA POSITION PROVIDES CEFOTETAN WITH A HIGH DEGREE OF STABILITY IN THE PRESENCE OF BETA-LACTAMASES INCLUDING BOTH PENICILLINASES AND CEPHALOSPORINASES OF GRAM-NEGATIVE BACTERIA.
Dosage
USUAL ADULT DOSAGE IS 1 OR 2 GRAMS ADMINISTERED IV OR IM EVERY 12 HOURS FOR 5 TO 10 DAYS. PROPHYLAXIS: RECOMMENDED DOSAGE IS 1 OR 2 G OF CEFOTETAN ONCE, INTRAVENOUSLY, 30 TO 60 MINUTES PRIOR TO SURGERY.
Drug Group
[ANTIBACTERIAL] , [ANTIBIOTIC] , [CEPHALOSPORIN] , [ANTI-INFECTIVES]
Cross Reaction
CONCOMITANT ADMINISTRATION OF AMINOGLYCOSIDES AND OTHER CEPHALOSPORINS HAS CAUSED NEPHROTOXICITY. DISULFIRAM-LIKE REACTION WITH ALCOHOL. POTENTIATES ANTICOAGULANTS.
Drug Interaction
Drugs Side Effect
Drug Categories
Special Precaution
Drug Safety
Monograph