PAZOPANIB IS A MULTI-TYROSINE KINASE INHIBITOR OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR (VEGFR)-1, VEGFR-2, VEGFR-3, PLATELET-DERIVED GROWTH FACTOR RECEPTOR (PDGFR)-ALPHA AND -BETA, FIBROBLAST GROWTH FACTOR RECEPTOR (FGFR)-1 AND -3, CYTOKINE RECEPTOR (KIT), INTERLEUKIN-2 RECEPTOR INDUCIBLE T-CELL KINASE (ITK), LEUKOCYTE-SPECIFIC PROTEIN TYROSINE KINASE (LCK), AND TRANSMEMBRANE GLYCOPROTEIN RECEPTOR TYROSINE KINASE (C-FMS). IN VITRO, PAZOPANIB INHIBITED LIGAND-INDUCED AUTOPHOSPHORYLATION OF VEGFR-2, KIT AND PDGFR-? RECEPTORS. IN VIVO, PAZOPANIB INHIBITED VEGF-INDUCED VEGFR-2 PHOSPHORYLATION IN MOUSE LUNGS, ANGIOGENESIS IN A MOUSE MODEL, AND THE GROWTH OF SOME HUMAN TUMOR XENOGRAFTS IN MICE.