AMIODARONE, DIGOXIN, ANTIARRHYTHMICS, ANTICONVULSANTS, SOME ANTIBIOTICS, SOME CALCIUM CHANNEL BLOCKERS SHOULD NOT BE CO-ADMINISTERED WITH SIMEPREVIR.
CO-ADMINISTRATION OF SIMEPREVIR WITH SUBSTANCES THAT ARE MODERATE OR STRONG INDUCERS OR INHIBITORS OF CYTOCHROME P450 3A (CYP3A) IS NOT RECOMMENDED AS THIS MAY LEAD TO SIGNIFICANTLY LOWER OR HIGHER EXPOSURE OF SIMEPREVIR, RESPECTIVELY, WHICH MAY RESULT IN REDUCED THERAPEUTIC EFFECT OR ADVERSE REACTIONS