GADOBENATE DIMEGLUMINE IS A PARAMAGNETIC AGENT AND, AS SUCH, DEVELOPS A MAGNETIC MOMENT WHEN PLACED IN A MAGNETIC FIELD. THE LARGE MAGNETIC MOMENT PRODUCED BY THE PARAMAGNETIC AGENT RESULTS IN A LARGE LOCAL MAGNETIC FIELD, WHICH CAN ENHANCE THE RELAXATION RATES OF WATER PROTONS IN ITS VICINITY LEADING TO AN INCREASE OF SIGNAL INTENSITY (BRIGHTNESS) OF TISSUE.
IN MAGNETIC RESONANCE IMAGING (MRI), VISUALIZATION OF NORMAL AND PATHOLOGICAL TISSUE DEPENDS IN PART ON VARIATIONS IN THE RADIOFREQUENCY SIGNAL INTENSITY THAT OCCUR WITH 1) DIFFERENCES IN PROTON DENSITY; 2) DIFFERENCES OF THE SPIN-LATTICE OR LONGITUDINAL RELAXATION TIMES (T1); AND 3) DIFFERENCES IN THE SPIN-SPIN OR TRANSVERSE RELAXATION TIME (T2). WHEN PLACED IN A MAGNETIC FIELD, GADOBENATE DIMEGLUMINE DECREASES THE T1 AND T2 RELAXATION TIME IN TARGET TISSUES. AT RECOMMENDED DOSES, THE EFFECT IS OBSERVED WITH GREATEST SENSITIVITY IN THE T1-WEIGHTED SEQUENCES.