PALMITOYLETHANOLAMIDE IS CONSIDERED AN ENDOGENOUS PPAR- AGONIST OR ACTIVATOR, INTERACTING WITH THIS RECEPTOR OR INHIBITS INFLAMMATORY PATHWAY & OXIDATIVE STRESS. DURING CHRONIC PAIN, PEA CAN MODULATE THE PPAR PATHWAY, THIS IA BLE TO ATTENUATE NFKB INDUCED INFLAMMATORY FACTORS( IL-1 OR TNF), INHIBIT INFILTRATION & ACTIVATION OF MC, REDUCE MESANGIAL MATRIX PROLIFERATION INDUCED BY REACTIVE OXIDATIVE STRESS(ROS) WHICH THEN RESULTED IN ALBUMINURIA.