IT IS A POTENT GASTROPROTECTIVE AGENT. IT INDUCES VASODILATATION IN GASTRIC MUCOSAL CIRCULATION & INCREASES GASTRIC BLOOD FLOW. SOFALCON INCREASES OXYGEN CONSUMPTION IN THE GASTRIC TISSUES AS REVEALED BY MEASURING INTRAVASCULAR PARTIAL PRESSURE OF OXYGEN. IN GASTRIC ULCER PATIENTS IT INCREASES THE QUANTITY OF PROSTAGLANDINS IN GASTRIC MUCOSA.
SOFALCONE IS A MUCOSAL PROTECTIVE AGENT THAT HAS BEEN REPORTED TO INHIBIT GROWTH OF HELICOBACTER PYLORI ON ADHERENCE BY PRODUCTION OF VACUOLATING TOXIN (VT), AND INDUCTION OF INTERLEUKIN-8 (IL-8) SECRETION BY H. PYLORI.
SOFALCONE HAS BEEN REPORTED TO HAVE AN ANTI-BACTERIAL EFFECT ON H. PYLORI AND THE INHIBITORY EFFECTS AGAINST THE PATHOGENIC FACTOR OF H. PYLORI IN ADDITION TO THE MUCOSAL PROTECTIVE EFFECT DUE TO THE INHIBITION OF PROSTAGLANDINS DEGRADATION ENZYME. SOFALCONE HAS A DIRECT BACTERICIDAL EFFECT ON H PYLORI, ANTI-UREASE ACTIVITY AND REDUCES THE ADHESION OF THIS ORGANISM TO GASTRIC EPITHELIAL CELLS