FOR OSTEOARTHRITIS THE RECOMMENDED DOSE IS 200 MG DAILY GIVEN BY MOUTH AS A SINGLE DOSE OR IN 2 DIVIDED DOSES. IF NECESSARY A DOSE OF 200 MG TWICE DAILY MAY BE USED. FOR RHEUMATOID ARTHRITIS THE DOSE IS 100 TO 200 MG GIVEN TWICE DAILY. IN ELDERLY PATIENTS TREATMENT SHOULD BE BEGUN AT THE LOWEST RECOMMENDED DOSE. IN THE USA, CELECOXIB IS ALSO USED FOR ANKYLOSING SPONDYLITIS IN AN INITIAL DOSE OF 200 MG DAILY, AS A SINGLE DOSE OR IN 2 DIVIDED DOSES. IF NECESSARY, THE DOSE MAY BE INCREASED TO 400 MG DAILY AFTER 6 WEEKS, ALTHOUGH IF NO RESPONSE IS SEEN AT THIS DOSE AFTER A FURTHER 6 WEEKS, ALTERNATIVE TREATMENTS SHOULD BE CONSIDERED.
IN THE TREATMENT OF PAIN AND DYSMENORRHOEA, AN INITIAL DOSE OF 400 MG FOLLOWED BY AN ADDITIONAL DOSE OF 200 MG, IF NECESSARY, IS RECOMMENDED ON THE FIRST DAY; THEREAFTER THE DOSE IS 200 MG TWICE .
* RENAL INSUFFICIENCY :- PATIENTS WITH SEVERE RENAL INSUFFICIENCY HAVE NOT BEEN STUDIED. * HEPATIC INSUFFICIENCY :- PATIENT WITH SEVERE HEPATIC IMPAIRMENT. THE USE OF CELECOXIB IS NOT RECOMMENDED. CELECOXIB IS NOT RECOMMENDED FOR THOSE PATIENTS WHO HAVE ADVANCED KIDNEY DISEASES.