THE HYPOGLYCEMIC ACTION OF SULFONYLUREA MAY BE POTENTIATED BY CERTAIN DRUGS
INCLUDING NONSTEROIDAL ANTI-INFLAMMATORY AGENTS AND OTHER DRUGS THAT ARE HIGHLY
PROTEIN BOUND, SALICYLATES, SULFONAMIDES, CHLORAMPHENICOL, PROBENECID,
COUMARINS, MONOAMINE OXIDASE INHIBITORS, AND BETA ADRENERGIC BLOCKING AGENTS.
CERTAIN DRUGS TEND TO PRODUCE HYPERGLYCEMIA AND MAY LEAD TO LOSS OF CONTROL.
THESE DRUGS INCLUDE THE THIAZIDES AND OTHER DIURETICS, CORTICOSTEROIDS,
PHENOTHIAZINES, THYROID PRODUCTS, ESTROGENS, ORAL CONTRACEPTIVES, PHENYTOIN,
NICOTINIC ACID, SYMPATHOMIMETICS, CALCIUM CHANNEL BLOCKING DRUGS, AND ISONIAZID.
BARBITURATES MAY PRODUCE DISULFIRAM LIKE ACTION. INTERACTION BETWEEN ORAL MICONAZOLE AND ORAL HYPOGLYCEMIC AGENTS LEADING TO SEVERE HYPOGLYCEMIA HAS BEEN REPORTED. WHETHER THIS INTERACTION ALSO OCCURS WITH THE INTRAVENOUS, TOPICAL, OR VAGINAL PREPARATIONS OF MICONAZOLE IS NOT KNOWN.
ALCOHOL MAY PRODUCE PROFOUND FACIAL FLUSHING.