CISPLATIN IS GIVEN BY INTRAVENOUS INFUSION IN SODIUM CHLORIDE 0.9% OR 5% DNS. IN MONOTHERAPY, IT IS USUALLY GIVEN AS A SINGLE DOSE OF 50 TO 120 MG/M2 EVERY 3 TO 4 WEEKS. ALTERNATIVELY, 15 TO 20 MG/M2 IS GIVEN DAILY FOR 5 DAYS, EVERY 3 TO 4 WEEKS. LOWER DOSES ARE GENERALLY USED FOR COMBINATION CHEMOTHERAPY REGIMENS; 20 MG/M2 OR MORE IS GIVEN ONCE EVERY 3 TO 4 WEEKS.
TESTICULAR TUMOURS : A DOSE OF 20 MG/M2 DAILY FOR 5 DAYS EVERY 3 TO 4 WEEKS HAS BEEN USED IN COMBINATION CHEMOTHERAPY OF TESTICULAR TUMOURS.
THE MANUFACTURERS RECOMMEND THAT CISPLATIN IS GIVEN IN 2 LITRES OF CHLORIDE-CONTAINING INFUSION FLUID. IN PRACTICE, VOLUMES OF LESS THAN 2 LITRES HAVE BEEN USED IN EXPERT CENTRES. THE INFUSION MAY BE GIVEN OVER 1 TO 2 HOURS, ALTHOUGH LICENSED PRODUCT INFORMATION GENERALLY RECOMMENDS A LONGER INFUSION TIME OF 6 TO 8 HOURS IN ORDER TO REDUCE RENAL AND GASTROINTESTINAL TOXICITIES.
TO AID DIURESIS AND PROTECT THE KIDNEYS, 37.5 G OF MANNITOL (E.G. 375 ML OF MANNITOL 10%) IS USUALLY ADDED TO THE INFUSION OR IS INFUSED SEPARATELY IMMEDIATELY BEFORE CISPLATIN.