SINCE CYCLOSPORINE MAY CAUSE HYPERKALEMIA, POTASSIUM-SPARING DIURETICS SHOULD NOT BE USED. WHILE CALCIUM ANTAGONISTS CAN BE EFFECTIVE AGENTS IN TREATING CYCLOSPORINE- ASSOCIATED HYPERTENSION, THEY CAN INTERFERE WITH CYCLOSPORINE METABOLISM. ADDITIVE NEPHROTOXICITY DUE TO AMINOGLYCOSIDS, AMPHOTERICIN B-1 CIPROFLOXACIN, COLCHICINE, MELPHALAN, CO-TRIMOXAZOLE, NSAIDS, CIMETIDINE, RANITIDINE, TACROLIMUS. CYCLOSPORINE BLOOD LEVELS INCREASED BY CALCIUM CHANNEL BLOCKERS LIKE DILTIAZEM, NICARDIPINE, VERAPAMIL, DOXYCYCLINE, ERYTHROMYCIN, KETOCONAZOLE, ITRACONAZOLE,FLUCONAZOLE, GLUCOCORTICOIDS LIKE METHYL-PREDNISOLONE, ORAL CONTRACEPTIVES,ALLOPURINOL, BROMOCRIPTINE, DANAZOL, METOCLOPRAMIDE, INDINAVIR,NELFINAVIR, RITONAVIR, GRAPE FRUIT AND GRAPEFRUIT JUICE. NAFCILLIN, OCTREOTIDE, TICLOPIDINE, CARBAMAZEPINE, ISONIAZID, PHENOBARBITONE, PHENYTOIN, RIFAMPICIN REDUCE CYCLOSPORINE LEVELS. METHOTREXATE CONC WERE INCREASED WHEN CONCOMMITANTLY USED. REDUCED CLEARANCE OF PREDNISOLONE, DIGOXIN, AND LOVASTATIN HAS BEEN OBSERVED