Name
DACTINOMYCIN
Mode of Action
DACTINOMYCIN IS A HIGHLY TOXIC ANTIBIOTIC WITH ANTINEOPLASTIC PROPERTIES. IT INHIBITS THE PROLIFERATION OF CELLS IN A CELL-CYCLE NONSPECIFIC WAY BY FORMING A STABLE COMPLEX WITH DNA AND INTERFERING WITH DNA-DEPENDENT RNA SYNTHESIS. IT MAY ENHANCE THE CYTOTOXIC EFFECTS OF RADIOTHERAPY. IT ALSO HAS IMMUNOSUPPRESSANT PROPERTIES.
Dosage
0.5 MG DAILY IV FOR MAX. 5 DAYS COURSE, REPEATED AFTER 3 OR MORE WEEKS. DOSE SHOULD NOT EXCEED 15 MCG/KG/BODY WT, OR 400 TO 600 MCG/METER BODY SURFACE. CHILDREN : 15 MCG/KG OF BODY WT. IV FOR 5 DAYS.
Drug Group
[ACTINOMYCIN] , [ANTICANCER] , [ANTINEOPLASTIC] , [IMMUNOSUPPRESSANT] , [MITOTIC INHIBITOR]
Cross Reaction
IT MAY INTERFERE WITH BIOSSARY PROCEDURES FOR THE DETERMINATION OF ANTIBACTERIAL DRUG LEVELS.
Drug Interaction
Drugs Side Effect
Drug Categories
Special Precaution
Drug Safety
Monograph