DIENOESTROL CAN BE ABSORBED FROM THE SKIN OR MUCOUS MEMBRANE & CAN CAUSE SYSTEMIC SUDE EFFECTS IF USED NONJUDICIALLY. REDUSES EFFECT BUT ENHANCES TOXIC EFFECTS OF IMIPRAMINE, REDUCES EFFECT OF ANTICOAGULANTS AND HYPOGLYCAEMIC, ANTIHYPERTENSIVE AGENTS. RIFAMPICIN, GRISEOVIN AND PHENYTOIN INCREASE RATE OF METABOLISM. ENHANCES ACTIVITY OF PHENYTOIN.REDUCES CLEARANCE OF CORTICOSTEROIDS, ALPRAZOLAM SO ENHANCES ITS EFFECT. INCREASES TOXICITY OF CYCLOSPORIN.DECREASED CLEARANCE OF XANTHINES. INCREASED CLEARANCE OF PARACETAMOL, MORPHINE, CLOFIBRATE.