Name
DOXAZOSIN
Mode of Action
IT IS A NEW QUINAZOLINE DERIVATIVES WITH A SELECTIVE INHIBITION OF THE ALPHA1 SUBTYPE OF ADRENERGIC RECEPTORS. THE ANTIHYPERTENSIVE ACTION IS PRODUCED BY REDUCTION IN THE SMOOTH MUSCLE TONE OF PERIPHERAL VASCULAR BEDS LEADING TO DECREASE IN THE TOTAL PERIPHERAL RESISTANCE WITHOUT SIGNIFICANT EFFECTS ON THE CARDIAC OUTPUT OR HEART RATE.
Dosage
HYPERTENSION : 1 MG AT BEDTIME, INCREASED AFTER 1-2 WEEKS. MAINTENANCE DOSE :- 4 MG ONCE DAILY, NOT TO EXCEED 16 MG DAILY. DOSES FOR BENIGN PROSTATIC HYPERPLASIA :- 2-4 MG DAILY, NOT TO EXCEED 8 MG DAILY.
Drug Group
[ALPHA-1 ADRENERGIC BLOCKER] , [ANTIHYPERTENSIVE] , [QUINAZOLINE DERIVATIVE]
Cross Reaction
CONCOMITANT USED WITH DIURETICS AND OTHER ANTIHYPERTENSIVES MAY ENHANCED HYPOTENSIVE EFFECTS OF IT. THE RISK OF FIRST DOSE HYPOTENSION MAY BE PARTICULARLY INCREASED IN PATIENTS RECEIVING BETA BLOCKERS OR CALCIUM-CHANNEL BLOCKERS.
Drug Interaction
Drugs Side Effect
Drug Categories
Special Precaution
Drug Safety
Monograph