REDUSES EFFECT BUT ENHANCES TOXIC EFFECTS OF IMIPRAMINE, REDUCES EFFECT OF ANTICOAGULANTS AND HYPOGLYCAEMIC, ANTIHYPERTENSIVE AGENTS. RIFAMPICIN, GRISEOVIN AND PHENYTOIN INCREASE RATE OF METABOLISM. ENHANCES ACTIVITY OF PHENYTOIN.REDUCES CLEARANCE OF CORTICOSTEROIDS, ALPRAZOLAM SO ENHANCES ITS EFFECT. CORTICOSTEROIDS DOSE IS TO BE DECREASED ONCE CONTRACEPTIVES ARE WITH HELD OTHERWISE CORTICOSTEROID TOXICITY MAY HAPPEN. INCREASES TOXICITY OF CYCLOSPORIN.DECREASED CLEARANCE OF XANTHINES. INCREASED CLEARANCE OF PARACETAMOL, MORPHINE, CLOFIBRATE.VIT B6 REDUCES ITS SERUM CONC, SO CHANCES OF CONTRACEPTIVE FAILURE ARE MORE