BREAST CANCER : INITIAL TREATMENT WITH HIGH DOSAGE PARENTERAL THERAPY. MAINT. : 1-2 TAB THRICE DAILY. INJ. : INITIAL TREATMENT : 500 MG I.V. DAILY FOR 5-10 DAYS, THEN 250 MG DAILY FOR 10-20 DAYS.
MENOPAUSAL SYNDROME:
VASOMOTOR SYMPTOMS - 1.25 MG DAILY, MODERATE TO SEVERE SYMPTOMS OF VULVAR AND VAGINAL ATROPHY - 0.3 MG TO 1.25 MG OR MORE DAILY. CONTINUE TREATMENT CYCLICALLY TILL FULL RESULTS ARE OBTAINED.
FEMALE HYPOGONADISM:
2.5 TO 7.5 MG DAILY,IN DIVIDED DOSES FOR 20 DAYS FOLLOWED BY A REST PERIOD OF 10 DAYS. IF BLEEDING OCCURS BEFORE THE END OF THE 10 DAY PERIOD, BEGIN A 20 DAY ESTROGEN-PROGESTIN CYCLIC REGIMEN WITH ESTROGENS TABLETS, 2.5 TO 7.5 MG DAILY IN DIVIDED DOSES, FOR 20 DAYS. DURING THE LAST 5 DAYS OF ESTROGEN THERAPY, GIVE AN ORAL PROGESTIN. IF BLEEDING OCCURS BEFORE THIS REGIMEN IS CONCLUDED, THERAPY IS DISCONTINUED AND MAY BE RESUMED ON THE FIFTH DAY OF BLEEDING.
FEMALE CASTRATION AND PRIMARY OVARIAN FAILURE:
1.25 MG DAILY, CYCLICALLY. ADJUST DOSAGE UPWARD OR DOWNWARD ACCORDING TO SEVERITY OF SYMPTOMS AND RESPONSE OF THE PATIENT. FOR MAINTENANCE, ADJUST DOSAGE TO LOWEST LEVEL THAT WILL PROVIDE EFFECTIVE CONTROL.
GIVEN CHRONICALLY: INOPERABLE PROGRESSING PROSTATIC CANCER:
1.25 TO 2.5 MG THREE TIMES DAILY.THE EFFECTIVENESS OF THERAPY CAN BE JUDGED BY PHOSPHATASE DETERMINATIONS AS WELL AS BY SYMPTOMATIC IMPROVEMENT OF THE PATIENT.
INOPERABLE PROGRESSING BREAST CANCER IN APPROPRIATELY SELECTED MEN AND POSTMENOPAUSAL WOMEN:
SUGGESTED DOSAGE IS 10 MG THREE TIMES DAILY FOR A PERIOD OF AT LEAST 3 MONTHS.