Monograph: |
Fluocortolone
An odourless or almost odourless, white to creamy-white.
crystalline powder. Practically insoluble in water and in
ether; very slightly soluble in alcohol and in methyl alcohol:
sparingly soluble in chloroform: slightly soluble in acetone
and in dioxan. Protect from light.
Fluocortolone and its esters are corticosteroids mainly used
topically for their glucocorticoid activity in the treat-
ment of various skin disorders. They are usually employed as
a cream or ointment; concentrations usually used are 0.25%
of the hexanoate with 0.25% of either the free alcohol or
pivalate ester. The pivalate and hexanoate esters have also
been used together in ointments or suppositories for the treat-
ment of anorectal disorders.
Fluocortolone free alcohol has been given by mouth for its
systemic effects, in usual doses of 5 to 100 mg daily.
When applied topically, particularly to large areas, when the
skin is broken, or under occlusive dressings, corticosteroids
mav be absorbed in sufficient amounts to cause systemic ef-
fects . The effects of topical corticosteroids on the
skin are described in flucinolone.
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