Monograph: |
Framycetin Sulphate
Framycetin is an antimicrobial substance produced by certain
strains of Streptomyces fradiae or Streptomyces decaris or by
any other means. It contains not more than 3% of neomycin
C and loses not more than 8% of its weight on drying.
A white or yellowish-white, hygroscopic powder containing
not less than 630 units of neomycin B per mg after drying.
Freely soluble in water, very slightly soluble in alcohol; prac-
tically insoluble in acetone and in ether. A 1% solution in wa-
ter has a pH of 6 to 7. Store in airtight containers. Protect
from light.
Framycetin is an aminoglycoside antibiotic which forms the
major component of neomycin and has similar ac-
tions and uses. It is used as the sulphate and is administered
topically in the treatment of infections of the skin, eye, and
car. It is often used in combination with other antibacterials
and corticosteroids in topical preparations.
Framycetin sulphate is poorly absorbed and has been given by
mouth for the treatment of gastro-intestinal infections and
pre-operatively for bowel preparation. It has sometimes been
given prophylactically as part of regimens for the selective
decontamination of the digestive tract in patients in intensive
care.
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