Monograph: |
Gas-gangrene Antitoxins
Gas-gangrene Antitoxin (Novyi) Gas-gangrene
Antitoxin (Oedematiens); Immunoserum Gangraenicum
(Clostridium Novyi): Nov/Ser) is a sterile preparation con-
taining the specific antitoxic globulins that have the power of
neutralising the alpha toxin formed by Clostridium novyi. It
has a potency of not less than 3750 international units (iu)
per mL.
Gas-gangrene Antitoxin (Perfringens) ,(Immuno-
serum Gangraenicum (Clostridium Perfringens). Perf/Ser) is
a sterile preparation containing the specific antitoxic globu-
lins that have the power of neutralising the alpha toxin formed
by Clostridium perfringens. It has a potency of not less than
1500 iu per mL.
Gas-gangrene Antitoxin (Septicum) (Ph. Eur.) (Immuno-
serum Gangraenicum (Clostridium Septicum); Sep/Ser) is a
sterile preparation containing the specific antitoxic globulins
that have the power of neutralising the alpha toxin formed by
Clostridium septicum. It has a potency of not less than 1500
iu per mL.
Mixed Gas-gangrene Antitoxin (Ph. Eur.) (Immunoserum
Gangraenicum Mixtum; Gas/Ser) is prepared by mixing Gas-
gangrene Antitoxin (Novyi), Gas-gangrene Antitoxin (Perf-
ringens and Gas-gangrene Antitoxin (Septicum) in appro-
priate quantities. It has a potency of not less than 1000 iu of
Gas-gangrene Antitoxin (Novyi), not less than 1000 iu of
Gas-gangrene Antitoxin (Perfringens), and not less than 500
iu of Gas-gangrene Antitoxin (Septicum) per mL.
The above antitoxins should be stored at 2Β° to 8Β°, and not be
allowed to freeze.
Gas-gangrene antitoxins have been used for the treatment of
gas gangrene and for prophylaxis in patients at risk following
injury. They are now seldom used and have been superseded
by antibacterials.
Suggested doses for a mixed gas-gangrene antitoxin were
25 000 units intravenously or intramuscularly for prophylaxis
and 75 000 units intravenously for treatment; these doses
might have been repeated or larger doses given initially.
Monovalent gas-gangrene antitoxins have been little used in
practice owing to the difficulty of rapidly identifying the in-
fecting organism.
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