GLUCOSAMINE
Recart Capsules
Chondroprotective agents have been defined as
compounds that can accomplish the following six
objectives in a joint.
β’ Enhance chondrocyte macromolecular synthesis
(Glycosaminoglycans, proteoglycans collagens,
proteins, RNA, DNA)
β’ Enhance synthesis of hyaluronic acid by synoviocytes
β’ Inhibit enzymes that degrade cartilage macromolecules
β’ Mobilize thrombi, fibrin, lipids, cholesterol deposits in
synovial spaces and blood vessels surrounding
joints(subchondral vessels)
' Reduce joint pain
β’ Reduce synovitis
At present, no single drug is able to accomplish all of these
objectives. A new approach is to combine compounds with
both overlapping and complementary functions . Such as a
combination of glucosamine and chondroitin sulfates.
Glucosamine - For matrix synthesis:
Glucosamine synthesis by chondrocytes appears to be the
key, rate-limiting step for synthesis of cartilage matrix.
Glucosamine itself constitutes half of hyaluronan, keratan
sulfates, heparan sulfates, and heparin. Glucosamine is
easily converted into galactosamine by epimerases, and
thus, constitutes half of chondroitin sulfates and dermatan
sulfates. In addition, almost every protein, including
collagen, is glycosylated with either glucosamine itself or a
derivative amino sugar. Thus, glucosamine is probably the
key single compound necessary for cartilage matrix
synthesis.
β’ Evidence has shown that exogenous glucosamine salt
significantly enhances chondrocyte synthesis of
glycosaminoglycan, collagen, and DNA.
' Glucosamine has been hypothesized to enhance
synthesis of synovial fluid hyaluronan.
' Although animal studies found that glucosamine did
not possess analgesic properties,it did exhibit
antiinflammatory effects against animal models
of inflammatory arthritis at high but safe doses.
' In addition, the numerous human studies of
glucosamine used for osteoarthritis, all exhibited
reductions in pain and joint inflammation.
Source: Dr. Theo.com
Uses: Recart contains compounds that provides both lubrication and protection to the articular surfaces of the bone, promoting ease of motion. At the same time, Recart nourishes these tissues with the key biochemical building block for cartilage synthesis, essential for joint function.
Recart contains glucosamine HCl, a newly available and readily absorbed form of this vital biochemical. Glucosamine is one of the major building blocks of articular cartilage and of synovial fluid, the lubricating and cushioning material in joints. Glucosamine is found in high concentrations in hyaluronic acid and glycosaminoglycans, a group of compounds that are responsible for proper hydration and moisture retention throughout the body.
In several recent studies, glucosamine was shown to have a positive effect on both joint mobility and joint inflammatory conditions. In these studies, glucosamine relieved the most overt symptoms of osteoarthrosis, including tenderness, pain, and restricted movement, outperforming aspirin, ibuprofen, and naproxen in alleviating these symptoms.
Glucosamine is an aminomonosaccharide naturally occurring
in the human body. It was tested for anti-inflammatory activities
and it showed to protect against the edema provoked in the rat
paw by carrageenin in, dextran, formalin, but not against the
edema provoked by specific inflammation mediators, such as
bradykinin, serotonin, histamine.
Glucosamine protected against pleuritis provoked in the rat by
carrageenin, but not against that provoked by bradykinin.
Furthermore glucosamine protected against peritonitis
provoked in the rat by formalin and in the mouse by acetic acid.
Glucosamine did not show antinociceptive properties against
writhings provoked by i.p. phenylquinone in the mouse.
Glucosamine did not show inhibiting activities on
cyclooxygenase or on the proteolytic enzymes in the inflamed
paw of the rat, but it was able to inhibit in vitro superoxide
generation and lysosomal enzymes of the liver.
The potency of glucosamine on the anti-inflammatory tests was
lower than that of acetylsalicylic acid and much lower than that
of indomethacin. Its acute toxicity, however, and notably the
toxicity on the gastrointestinal tract is very low, practically
absent. The pharmacological therapeutic index of glucosamine
with regard to the anti-inflammatory activities seems therefore
comparable or superior to that of the known non-steroidal anti-
inflammatory drugs.
Glucosamine hydrochloride vs. Glucosamine sulphate : the study shows that since chloride ion is the natural ion of stomach so glucosamine hcl is more fully absorbed in comparison to glucosamine sulphate ( 83.1%/60.3%).
The glucosamine selected for Recart is a 100% pure, natural form for maximum bioactivity. Owing to its high solubility, it is readily absorbed from the gastrointestinal tract and actively taken up by an incorporated into articular cartilage.
Manganese sulfate is included to assist in the endogenous production of glycosaminoglycans.
Directions: Take 2 capsules per day, preferably with meals. Recart can be taken all at once or divided throughout the day, as desired.