Monograph: |
Human Rabies Immunoglobulin (Antirabies 1m-
munoglobulin Injection; Rabies Immunoglobulin ;
is a liquid or freeze-dried preparation containing human
immunoglobulins, mainly immunoglobulin G (lgG). It is obtained
from plasma from donors immunised against rabies and contains
specific antibodies that neutralise the rabies virus. Normal
immunoglobulin may be added. It contains not less than 150
international units per mL. The liquid preparation should be
stored, protected from light, in a colourless, glass container.
The freeze-dried preparation should be stored, protected from
light, in a colourless, glass container, under vacuum or under
an inert gas.
Rabies Immune Globulin (USP 23) is a sterile solution of
globulins derived from plasma or serum from selected adult
human donors who have been immunised with rabies vaccine
ai;d have developed high titres of rabies antibody. It contains
10 to 18% of protein of which not less than 80% is monomer-
ic immunoglobulin G. It contains glycine as a stabilising
agent, and a suitable preservative. A solution diluted to con-
tain I % of protein has a pH of 6.4 to 7.2. It should be stored
at 2Β° to 8Β°.
Adverse Effects and Precautions
As for immunoglobulins in general.
Uses and Administration
Rabies immunoglobulins are used for passive immunisation
against rabies. They are used in conjunction with active im-
munisation with rabies vaccines (see below) as part of the
post exposure treatment for the prevention of rabies in previ-
ously unimmunised persons who have been bitten by rabid
animals or animals suspected of being rabid. The recom-
mended dose of rabies immunoglobulin is 20 international
units per kg body-weight, up to half of which should be infil-
trated around the wound with the remainder being given intra-
muscularly at a different site to that at which the vaccine was
administered.
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