Monograph: |
L-Isoleucine
Isoleucine benefits patients with Peptic Ulcer or Esophageal
varices induced by liver cirrhosis. When there
is a gastro intestinal bleeding in these patients, there is a
decrease in Isoleucine levels, by more than 60% in blood
plasma. Experimental studies also prove that gastro intestinal
bleeding lead to Hypoisoleucinemia and decrease
tissue Isoleucine pool.
Isoleucine has been identified as one of a group of amino acids
deficient in mentally and physically ill patients'
Leucine (like Isoleucine) is also found to be relatively
deficient in mentally and physically ill patients.
Valine is useful in muscle development, mental and emotional
upsets and in insomnia and nervousness.
Isoleucine, Leucine & Valine are reported to be essential to
restore positive Nitrogen balance in human subjects.
These Branched Chain Amino Acids (BCAAs) being liver independent,
acts as a ready source of energy, in
condition of depletion. They offer Myocardial protection by
stimulating the formation of Acetyl- OB, and
succinyl COA thereby ensuring recovery of oxidation Metabolism."
People who trek high altitude benefit from BCAAs. Their arm
muscle cross section area tend to increase, so also
their lean mass increases.
BCAAs, particularly Leucine stimulate protein synthesis, increase
reutilisation of amino acids in many organs and
reduce protein breakdown. Leucine stimulates insulin release,
which in turn stimulates protein synthesis and
inhibits protein breakdown.
|