Monograph: |
Glycine( aminoacetic acid)
A white odouriess crystalline powder. Soluble 1 in 4 of water
at 25, 1 in 2.6 at 50Β°, 1 in 1.9 at 75Β°. and 1 in 1.5 at 100Β°;
soluble I in 1254 of alcohol: very slightly soluble or practi-
cally insoluble in ether. A 5% solution in water has a pH of
5.9 to 6.4.
Adverse Effects and Precautions
Systemic absorption of glycine irrigation solutions can lead to
disturbances of fluid and electrolyte balance and cardiovascu-
lar and pulmonary disorders.
Glycine irrigation should be used cautiously in pariems with
hepatic impairment since any absorption and consequent me-
tabolism may cause hyperammonaemia. The possible effects
on fluid and electrolyte balance warrant cautious use in pa-
tients with caidiopulmonary or renal dysfunction: glycine ir-
rigation is contra-indicated in anuric patients.
Reports and discussions concerning adverse effects, includ-
ing disturbances of fluid and electrolyte balance, after the use
of glycine irrigation solutions and precautions to be observed.
Uses and Administration
Glycine is the simplest of the amino acids. It is used as a die-
tary supplement.
Glycine is sometimes used in conjunction with antacids in the
treatment of gastric hyperacidity. It is also used as an ingredi-
ent of some aspirin preparations with the object of reducing
gastric irritation.
Sterile solutions of glycine 1.5% in water, which are hypoton-
ic and non-conductive, are used as urogenital irrigation solu-
tions during certain surgical procedures, particularly
transurethral resection of the prostate.
Glycine hydrochloride has also been used.
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