Monograph: |
Lysine Acetylsalicylate
Lysine aspirin (Lysine acetylsalicylate ) 900 mg is
approximately equivalent to 500 mg
of aspirin.
Adverse Effects, Treatment, and Precautions
As for Aspirin. Shock has been reported in patients giv-
en lysine aspirin by injection.
Lysine aspirin, like aspirin, should not generally be given to
children under the age of 12 years because of the risk of
Reye's syndrome.
Interactions
For interactions associated with aspirin.
Uses and Administration
Lysine aspirin has analgesic, anti-inflammatory, and antipy-
retic actions similar to those of aspirin . Following
administration, lysine aspirin dissociates into lysine and aspi-
rin; aspirin is then hydrolysed to salicylic acid. Lysine
aspirin
is used in the treatment of pain, fever, and rheumatic disor-
ders. It is given by mouth in doses equivalent to 0.5 to I g of
aspirin, repeated every 4 hours as needed up to a maximum of
3 g of aspirin daily (2 g daily in the elderly) for pain and
fever.
The dose for rheumatic disorders is 4 to 6 g of aspirin daily in
3 or 4 divided doses. Lysine aspirin is also given intramuscu-
larly or intravenously in similar doses: the maximum daily
parenteral dose is 4 g of aspirin for very severe pain and 6 g
of aspirin for rheumatic disorders.
Lysine aspirin is also used in combination with metoclopra-
mide in the treatment of migraine.
Lysine aspirin has also been used in the management of
thrombo-embolic disorders.
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