Monograph: |
Noscapine
Noscapine is an alkaloid obtained from opium. It occurs as
colourless crystals or as a fine white or practically white
crystalline powder.
Practically Insoluble in water at 20Β°, very slightly soluble
at 100Β°; slightly soluble in alcohol and in ether: soluble in
acetone; freely soluble in chloroform; dissolves in strong
acids although the base may be precipitated on dilution with
water.
Protect from light.
Adverse Effects and Precautions
As for Dextromethorphan, p. 1057. Hypersensitivity reactions
have been reported.
The CSM in the UK have stood by their recommendation
that products containing noscapine should be contra-indicat-
ed in women of child-bearing potential (because of potential
mutagenic effects') after criticism that the decision was based
solely on the results of in-vitro work.
Interactions
Noscapine should not be given concomitantly with alcohol or
other CNS depressants.
Pharmacokinetics
Uses and Administration
Noscapine is a centrally acting cough suppressant that has ac-
tions and uses similar to those of dextromethorphan hydro-
bromide . It is given by mouth in a dose of up to
50 mg three times a day. It has also been given as the cam-
sylate, embonate, and the hydrochloride.
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