Monograph: |
Nylidrin Hydrochloride:
An odourless, white, crystalline powder. Soluble I in 65 of
water and I in 40 of alcohol; slightly soluble in chloroform
and ether. A I % solution in water has a pH of 4.5 to 6.5. Store
in airtight containers.
Adverse Effects and Precautions
For the adverse effects of sympathomimetics and precautions
to be observed, see under Adrenaline.
Uses and Administration
Nylidrin produces peripheral vasodilatation through beta-
adrenoceptor stimulation and a direct action on the arteries
and arterioles of the skeletal muscles.
Nylidrin has been used in the treatment of disorders of pe-
ripheral and cerebral circulatory insufficiency. It has also
been used in preparations for rhinitis and nasal congestion.
The usual dose of nylidrin hydrochloride was 3 to 12 mg by
mouth three or four times daily.
An intravenous infusion of nylidrin hydrochloride has been
used to arrest premature labour. It has also been given orally
as a prophylactic tocolytic agent.
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