Monograph: |
Octinum Mucate
A white crystalline powder. Very soluble or freely soluble in
water; soluble in alcohol; slightly soluble in absolute alcohol;
very slightly soluble or practically insoluble in chloroform;
practically insoluble in ether. The BP specifies that a 5% so-
lution has a pH of 5.4 to 6.6; the USP specifies a pH of 6.0 to
7.5. Store in airtight containers. Protect from light.
Adverse Effects and Precautions
For the adverse effects of sympathomimetics. and precautions
to be observed, see adrenaline.
Porphyria. Octinum mucate has been associated with
clinical exacerbations of porphyria and is considered unsafe
in porphyric patients.
Interactions
For the interactions of sympathomimetics in general, see
Adrenaline. Octinum has been reported to produce severe hy-
pertensive reactions in patients receiving MAOls.
For a report of hypertension and life-threatening complica-
tions following concomitant use of octinum and bro-
mocriptine, see under Sympathomimetics, like adrenaline.
Uses and Administration
Octinum is an indirect-acting sympathomimetic (see
Adrenaline ). It is included for its vasoconstrictor effect,
usually as
the mucate, in some analgesic combination products used to
treat acute migraine attacks . Typical doses of octinum mucate in
migraine are 130 mg at the beginning
of an attack with 65 mg hourly thereafter as necessary up to a
total maximum dose of 325 mg in a 12-hour period.
Octinum as the hydrochloride and as the mucate is also
used in the management of smooth muscle spasm. Usual dos-
es of the hydrochloride in painful muscle spasm or migraine
are 75 to 100 mg by mouth 3 or 4 times daily, although higher
doses have been given. It is also given by intramuscular, or
occasionally subcutaneous or slow intravenous injection.
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