Monograph: |
Oxyphenbutazone
A white to yellowish-white, odourless, crystalline powder.
Practically Insoluble in water: soluble I in 1.5 of alcohol. I ir
4 of chloroform, and I in 15 of ether; freely soluble in ace-
tone; it dissolves in dilute solutions of alkali hydroxides,
Store in airtight containers. Protect from light.
Adverse Effects and Precautions
As for Phenylbutazone. Adverse effects on the blood
may be more frequent with oxyphenbutazone than with phe-
nylbutazone.
Porphyria : Oxyphenbutazone has been associated with clin-
ical exacerbations of porphyria and is considered unsafe in
porphyric patients.
Interactions
For interactions associated with NSAIDs. see Ibuprofen.
Uses and Administration
Oxyphenbutazone. a metabolite of phenylbutazone is
an NSAID . It has been applied topically to the eye as
an anti-inflammatory ointment (usually 10%) in conditions
such as episcleritis. Oxyphenbutazone was used systemically
in disorders such as ankylosing spondylitis, osteoarthritis
and rheumatoid arthritis but such use is no longer considered
justified owing to the risk of severe haematological adverse
effects.
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