Monograph: |
Phenylmercuric acetate
The properties are similar to phenyl mercuric nitrate, so see below at phenyl mercuric
nitrate record for the details.
Adverse Effects and Precautions
While the adverse effects of inorganic mercury
should be taken into account when consid-
ering the adverse effects of phenylmercuric com-
pounds. there is little evidence of systemic toxicity
arising from their use. They are irritant to the skin
and may give rise to erythema and blistering. Hyper-
sensitivity reactions have been reported. Topical ap-
plication to eyes has been associated with
mercurialentis and atypical band keratopathy; pro-
longed use of eye drops containing phenylmercuric
preservatives is not recommended.
Effects on the eyes. References to primary atypical band
keratopathy and pigmentation of the anterior capsule of the
lens (mercurialentis) associated with the prolonged use of eye
drops containing phenylmercuric preservative.
Uses
Phenylmercuric salts have antibacterial and antifun-
gal properties. They are primarily bacteriostatic
compounds although they also have a slow bacteri-
cidal action. Their activity has been reported to be
pH dependent.
Phenylmercuric compounds are used as preserva-
tives in cosmetic, ophthalmic, or pharmaceutical
preparations and as antiseptics. They have also been
used as spermicides.
When employed as a preservative in eye drops, a
concentration of 0.002% is usually used; in injection
solutions the concentration is 0.001%.
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