Monograph: |
Reviparin Sodium
Reviparin sodium is prepared by nitrous acid depolymerisa-
tion of heparin obtained from the intestinal mucosa of pigs.
The majority of the components have a 2-O-sulpho-a-L-
idopyranosuronic acid structure at the non-reducing end and
a 6-0-sulpho-2.5-aiihydro-D-mannitol structure at the reduc-
ing end of their chain. The mass-average molecular mass
ranges between 3150 and 5150 with a characteristic value of
about 4150. The degree of sulphation is about 2.1 per disac-
charide unit.
Reviparin sodium is a low-molecular-weight heparin
with anticoagulant activity used in the prevention of postop-
erative venous thrombo-embolism.
|