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SOD PHOSPHATE
ACTION AND USES
EXIT® Enema is useful as a laxative in the relief of occasional constipation, and as part of a bowel cleansing regimen in preparing the patient for surgery or for preparing the colon for x-ray and endoscopic examination. Used as directed, EXIT® Enema provides thorough yet safe cleansing action and induces complete emptying of the left colon usually within 2 to 5 minutes without pain or spasm. Also used for general postoperative care and to help relieve fecal or barium impaction.
GENERAL LAXATIVE WARNINGS
Using more than one enema in 24 hours can be harmful.
Do not use laxative products when nausea, vomiting, or abdominal pain is present unless directed by a physician. If you notice a sudden change in bowel habits that persists over a period of 2 weeks, consult a physician. Rectal bleeding or failure to have a bowel movement after use of a laxative may indicate a serious condition. Discontinue use and consult a physician. Laxative products should not be used longer than 1 week unless directed by a physician. As with any drug, if you are pregnant or nursing a baby, seek the advice of a health professional before using this product. Keep this and all drugs out of the reach of children. In case of accidental overdose or ingestion, seek professional assistance or contact a Poison Control Center immediately.
PROFESSIONAL USE WARNINGS
Do not use in patients with congenital megacolon, bowel obstruction, imperforate anus or congestive heart failure.
Use with caution in patients with impaired renal function, pre-existing electrolyte disturbances or in patients on diuretics or other medications which may affect electrolyte levels--or where colostomy exists.
Since EXIT® Enema contains sodium phosphates, there is a risk of elevated serum levels of sodium and phosphate and decreased levels of calcium and potassium and consequently hypocalcemia, hyperphosphatemia, hypernatremia, and acidosis may occur. This is of particular concern in children with megacolon or any other condition where there is retention of enema solution.
Additional fluids by mouth are recommended with all bowel cleansing dosages.
OVERDOSAGE
Overdosage or retention of EXIT® Enema may cause hypocalcemia, hyperphosphatemia, hypernatremia, hypernatremic dehydration and acidosis.
Calcium, phosphate, potassium and sodium levels should be carefully monitored. Immediate corrective action should be taken to restore electrolyte balance with appropriate fluid replacements. Prompt parenteral administration of fluids with lower concentrations of sodium and chloride than extracellular fluid (40-50 mEq/liter) and moderate concentration of potassium (20-30 mEq/liter) administered at a rate of 3,000 to 4,000 cc/sq. m of body surface during the first 12 to 24 hours is dependent on the severity of dehydration and the clinical response.
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