Monograph: |
ANTAZOLINE
A white to off-white crystalline powder. Soluble in water:
sparingly soluble in methyl alcohol; practically insoluble in
ether. A 2% solution in water has a pH of 4 to 5. Store in
airtight containers.
Antazoline Sulphate
Adverse Effects and Precautions
As for the antihistamines in general .
Hypersenstivity. Reports of acute interstitial pneumonitis
(with fever, rash. and dyspnoea)' and of immune thrombocy-
topenic purpura' were attributed to hypersensitivity reactions
following the oral administration of antazoline.
Uses and Administration
Antazoline, an ethylenediamine derivative, is an antihista-
mine used topically for the treatment of allergic conjunctivitis.
It is used as the hydrochloride, phosphate, or sul-
phate in eye drops, most commonly in a concentration of
0.5%: the mesylate has also been used. Antazoline salts are
often used with a vasoconstrictor such as naphazoline hydro-
chloride or nitrate or xylometazoline hydrochloride.
Antazoline hydrochloride is used in a strength of up to 2% in
a cream or ointment for the treatment of minor skin irrita-
tions, but as with other antihistamines there is a risk of sensi-
tisation. The hydrochloride has also been given by mouth.
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