Monograph: |
Mebhydrolin
Mebhydrolin Napadisylate
Mebhydrolin napadisylate 152 mg is approximately equiva-
lent to 100 mg of mebhydrolin.
Adverse Effects and Precautions
As for the sedating antihistamines like promethazine in general.
Granulocytopenia and agranulocytosis have been reported.
Interactions
As for the sedating antihistamines in general.
Pharmacokinetics
Mebhydrolin is absorbed slowly from the gastro-intestinal
tract. It is extensively metabolised: only small amounts of un-
changed drug are recovered in the urine. The manufacturers
of mebhydrolin give a plasma half-life of about 4 hours.
Uses and Administration
Mebhydrolin, an ethylenediamine derivative, is a sedating an-
tihistamine with antimuscarinic and sedative properties. It has
been used for the symptomatic relief of allergic conditions
including urticaria and rhinitis and in pruritic
skin disorders .
Mebhydrolin is administered by mouth as the base or as the
napadisylate salt. Doses are expressed in terms of the equiva-
lent amount of mebhydrolin base and the usual dose has been
50 to 100 mg three times daily.
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