Monograph: |
Biphasic Insulin
Biphasic insulins are mixtures providing for both
immediate and prolonged action.
In order to prolong the duration of action of insulin,
preparations may be formulated as suspensions in 2
general ways. The first involves complexing insulin
with a protein from which it is slowly released; ex-
amples are protamine zinc insulin, which contains
an excess of protamine, and isophane insulin,
which contains equimolecular amounts of insulin
and protamine. The second method of prolonging
the action of insulin is to modify the particle size and
the various insulin zinc suspensions are in this cat-
egory.
The suspension of crystals could be in bovine insulin or in a solution of
porcine insulin.
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