Monograph: |
Loprazolam Mesilate
A yellow crystalline powder. Slightly soluble in water, in alcohol, and in chloroform; very slightly soluble in ether.
Dependence and Withdrawal
As for Diazepam.
For the purpose of withdrawal regimens, 0.5 to 1 mg of loprazolam is considered equivalent to about 5 mg of diazepam.
Adverse Effects, Treatment, and Precautions
As for Diazepam.
Porphyria.
Loprazolam is considered to be unsafe in patients with porphyria because it has been shown to be porphyrinogenic in in-vitro systems.
Interactions
As for Diazepam.
Pharmacokinetics
Uses and Administration
Loprazolam is an intermediate-acting benzodiazepine with general properties similar to those of diazepam.
Loprazolam mesilate is usually used for its hypnotic properties in the short-term management of insomnia, in usual doses equivalent to 1 mg of loprazolam at night. Dosage may be increased to up to 2 mg if necessary. A starting dose of 0.5 mg increased to a maximum of 1 mg may be appropriate for elderly or debilitated patients.
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