Monograph: |
Temocillin
Temocillin is a semisynthetic penicillin that is highly resistant to a wide range of beta-lactamases and is used for the treatment of infections caused by beta-lactamase-producing strains of Gram-negative aerobic bacteria, including those resistant to third-generation cephalosporins.
It is given as the sodium salt and doses are expressed in terms of the base; 1.11 g of temocillin sodium is equivalent to about 1 g of temocillin. It is given by intravenous or intramuscular injection or by intravenous infusion in usual doses of 1 g every 12 hours. A dose of 12.5 mg/kg every 12 hours may be used in children. Intravenous doses may be doubled in severe infections.
In patients with renal impairment the interval between doses may need to be increased.
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