Monograph: |
ACOTIAMIDE HYDROCHLORIDE IS A NOVEL SELECTIVE ACETYLCHOLINESTERASE (ACHE) INHIBITOR. ACETYLCHOLINE IS AN IMPORTANT NEUROTRANSMITTER TO REGULATE GASTROINTESTINAL MOTILITY, AND THROUGH THE INHIBITION OF DEGRADATION OF ACETYLCHOLINE, ACOTIAMIDE PRODUCES THE IMPROVEMENT OF IMPAIRED GASTRIC MOTILITY AND DELAYED GASTRIC EMPTYING, AND CONSEQUENTLY THE SYMPTOMS OF FUNCTIONAL DYSPEPSIA. IT IS USUALLY USED FOR THE TREATMENT OF POSTPRANDIAL FULLNESS, UPPER ABDOMINAL BLOATING, AND EARLY SATIATION DUE TO FUNCTIONAL DYSPEPSIA.
ACOFIDE® IS AVAILABLE AS FILM-COATED TABLET FOR ORAL USE, CONTAINING 100 MG OF ACOTIAMIDE HYDROCHLORIDE HYDRATE. IN GENERAL, FOR ADULTS, TAKE 1 TABLET AT A TIME, 3 TIMES A DAY BEFORE MEALS.
ACOTIAMIDE HYDROCHLORIDE IS THE HYDROCHLORIDE SALT FORM OF ACOTIAMIDE , A PROKINETIC AGENT WITH GASTROINTESTINAL (GI) MOTILITY-ENHANCING ACTIVITY. ALTHOUGH THE EXACT MECHANISM BY WHICH ACOTIAMIDE EXERTS ITS EFFECT HAS YET TO BE FULLY ELUCIDATED, THIS AGENT APPEARS TO INHIBIT ACETYLCHOLINESTERASE (ACHE), AN ENZYME RESPONSIBLE FOR THE BREAKDOWN OF ACETYLCHOLINE (ACH). INCREASED ACH CONCENTRATIONS LEAD TO AN IMPROVEMENT OF GASTRIC EMPTYING AND GI MOTILITY AND EVENTUALLY TO A REDUCTION OF DYSPEPSIA SYMPTOMS.
ACOTIAMIDE HYDROCHLORIDE IS THE HYDROCHLORIDE SALT FORM OF ACOTIAMIDE , A PROKINETIC AGENT WITH GASTROINTESTINAL (GI) MOTILITY-ENHANCING ACTIVITY. ALTHOUGH THE EXACT MECHANISM BY WHICH ACOTIAMIDE EXERTS ITS EFFECT HAS YET TO BE FULLY ELUCIDATED, THIS AGENT APPEARS TO INHIBIT ACETYLCHOLINESTERASE (ACHE), AN ENZYME RESPONSIBLE FOR THE BREAKDOWN OF ACETYLCHOLINE (ACH). INCREASED ACH CONCENTRATIONS LEAD TO AN IMPROVEMENT OF GASTRIC EMPTYING AND GI MOTILITY AND EVENTUALLY TO A REDUCTION OF DYSPEPSIA SYMPTOMS.
CHOLINESTERASE INHIBITORS
DRUGS THAT INHIBIT CHOLINESTERASES. THE NEUROTRANSMITTER ACETYLCHOLINE IS RAPIDLY HYDROLYZED, AND THEREBY INACTIVATED, BY CHOLINESTERASES. WHEN CHOLINESTERASES ARE INHIBITED, THE ACTION OF ENDOGENOUSLY RELEASED ACETYLCHOLINE AT CHOLINERGIC SYNAPSES IS POTENTIATED. CHOLINESTERASE INHIBITORS ARE WIDELY USED CLINICALLY FOR THEIR POTENTIATION OF CHOLINERGIC INPUTS TO THE GASTROINTESTINAL TRACT AND URINARY BLADDER, THE EYE, AND SKELETAL MUSCLES; THEY ARE ALSO USED FOR THEIR EFFECTS ON THE HEART AND THE CENTRAL NERVOUS SYSTEM.
IT IS USED FOR THEIR EFFECTS ON THE GASTROINTESTINAL SYSTEM, AS TO CONTROL GASTRIC ACIDITY, REGULATE GASTROINTESTINAL MOTILITY AND WATER FLOW, AND IMPROVE DIGESTION.
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