Monograph: |
Clobetasone Butyrate
A white or almost white powder. Practically insoluble in wa-
ter: slightly soluble in alcohol; freely soluble in acetone and
in dichloromethane. Protect from light.
Clobetasone butyrate is a corticosteroid used topically for its
glucocorticoid effects in the treatment of various
skin disorders. It is usually employed as a cream or ointment
containing 0.05%. It is also used for inflammatory eye disor-
ders, as eye drops containing 0.l%.
When applied topically, particularly to large areas, when the
skin is broken, or under occlusive dressings, corticosteroids
may be absorbed in sufficient amounts to cause systemic ef-
fects . Prolonged application to the eye
of preparations containing corticosteroids has caused raised
intra-ocular pressure and reduced visual function.
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