Monograph: |
Dibucaine
The properties are the same as of Cinchocaine Hcl , so see below at Cinchocaine Hcl record for the
details.
Cinchocaine Hydrochloride
NOTE. This compound was originally marketed under the
name Percaine. but accidents occurred owing to the confusion
of this name with procaine.
Fine. colourless or white to off-white, odourless, crystals or
white to off-white crystalline powder: it is hygroscopic, M.p.
96Β° to 100Β°. It agglomerates very easily. Very to freely solu-
ble in water: freely soluble in alcohol, in acetone, in chloro-
form. and in dichloromethane. A 2% solution in water has a
pH of 5.0 to 6.0. Cinchocaine hydrochloride darkens on expo-
sure to light. Store in airtight containers. Protect from light.
Cinchocaine is an amide local anaesthetic that is
now generally used for surface anaesthesia. It is one of the
most potent and toxic of the long-acting local anaesthetics
and its parenteral use was restricted to spinal anaesthesia.
For surface anaesthesia cinchocaine has been used. as the
base or hydrochloride, in creams and ointments containing up
to 1.0% and in suppositories for the temporary relief of pain
and itching associated with skin and anorectal conditions.
Cinchocaine benzoate has also been used topically.
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