Monograph: |
Drotaverine
PRESENTATION:
Each DROTIN tablet contains 40 mg Drotaverine Hydrochloride.
Each DROTIN DS tablet contains 80 mg Drotaverine Hydrochloride.
Each DROTIN Injection 2 ml ampoule contains 40 mg Drotaverine
Hydrochloride.
INDICATIONS:
Tablet : Spastic conditions of the gastrointestinal tract :
Biliary
colic and spastic conditions of the biliary tract ;
cholelithiasis,
choledolithiasis, cholecystitis ; Renal colic and spastic
conditions
of the urogenital tract ; nephrolithiasis, ureterolithiasis,
Dysmenorrhea, Post-MTP and D&C.
Infection : As an emergency antispasmodic medicine for acute
gastrointestinal colics, biliary colics, renal colics and severe
dysmenorrhea.
Hastening cervical dilatation during normal vaginal delivery.
DOSAGE:
Tablets:
Adults(Abovel2years) : DROTIN DS one tablet 3 times a day.
Children between 1 to 6 years : DROTIN half tablet 3 times a
day.
Children between 6 to 12 years : DROTIN one tablet 3 times a
day.
Injection: For acute colics in adults; one to two ampoules of
Drotin
Injection I M/ slow intravenous (IV) upto three times a day.
In labour (Active phase of first stage at three (3) cm cervical
dilatation or more); one ampoule of Drotin Injection to be
administered intramuscularly (I M), which can be repeated after
βtwo-hourly intervals.
USE IN PREGNANCY:
As indicated by animal reproductive studies and supported by
more than 30 years of usage, Drotaverine has shown no
significant
increase in congenital anomalies. Thus Drotaverine can be said
to have no embryotoxic or teratogenic effects.
ADVERSE REACTIONS;
Too rapid intravenous injections should be avoided in order to
prevent
drop in arterial blood pressure. In rare cases, nausea and
vertigo
may occur after rapid IV Injection.
DRUG INTERACTIONS:
Levodopa (Antiparkinson effect may decrease)
FURTHER INFORMATION:
DROTIN is a musculotropic antispasmodic drug acting directly on
smooth muscle cells. DROTIN produces smooth muscle relaxation
particularly where spasm exists. The action does not involve the
autonomic nervous system, hence DROTIN is free from
anticholinergic like side effects. DROTIN can be administered to
patients suffering from glaucoma and prostatic hypertrophy when
anticholinergic antispasmodics are contraindicated.
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